|Calculated MW||43770 Da|
|Purification||Antisera to Wnt2b were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Synthetic peptide - internal domain of human Wnt2b.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Protein Wnt-2b, Protein Wnt-13, WNT2B, WNT13|
|Target/Specificity||ABD10919 detects an epitope within the internal region (IN) of human Wnt2b, also known as Wnt13. Wnt2b is a signalling factor which acts as a ligand for members of the frizzled family of seven transmembrane receptors. It is thought to play a key role during mammalian early embryogenesis, and may also function as a stem cell factor for neural and retinal progenitor cells. The Wnt2b gene encodes two alternative transcript variants; Wnt2B splicing variant 1 encodes secreted-type glycoprotein (Wnt2B isoform 1), while Wnt2B splicing variant 2 encodes a transmembrane-type glycoprotein (Wnt2B isoform 2). Wnt2b has been implicated in gastric cancer, esophageal cancer and skin basal cell carcinoma.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-WNT2B Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Katoh M. (2005) WNT2B: comparative integromics and clinical applications. Int. J. Mol. Med. 16: 1103-1108.
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