|Calculated MW||108565 Da|
|Purification||Antisera to USP4 were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Synthetic peptide: Internal domain of human USP4.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Ubiquitin carboxyl-terminal hydrolase 4, 220.127.116.11, Deubiquitinating enzyme 4, Ubiquitin thioesterase 4, Ubiquitin-specific-processing protease 4, Ubiquitous nuclear protein homolog, USP4, UNP, UNPH|
|Target/Specificity||ABD10921 detects an epitope within the internal region of ubiquitin specific protease 4 (USP4), a 105kD protein also known as ubiquitous nuclear protein (UNP). USP4 binds to the retinoblastoma family of tumour suppressor proteins, including pRb, p107 and p130. USP4 shuttles between the nucleus and cytoplasm and is thought to be an oncogene, with elevated expression in small cells tumours and adenocarcinomas of the lung.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human USP4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Blanchette, P. et al. (2001) Association of UNP, a ubiquitin-specific protease, with the pocket proteins pRb, p107 and p130. Oncogene. 20: 5533-5537.2. Soboleva, T.A. et al. (2005) Nuclear-Cytoplasmic shuttling of the oncogenic mouse UNP/USP4 deubiquitylating enzyme. J. Bio. Chem. 280: 745-752.3. DeSalle, L.M. et al. (2001) The de-ubiquitinating enzyme Unp interacts with the retinoblastoma protein. Oncogene. 20: 5538-5542.
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