|Calculated MW||72456 Da|
|Purification||Antisera to SLC5A4 were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Synthetic peptide to the C-terminal domain of human SLC5A4, conjugated to KLH.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Low affinity sodium-glucose cotransporter, Sodium/glucose cotransporter 3, Na(+)/glucose cotransporter 3, Solute carrier family 5 member 4, SLC5A4, SAAT1, SGLT2|
|Target/Specificity||ABD10923 detects an epitope within the C-terminal (CT) region of Na+-coupled glucose transporter 3 (SGLT2), also known as SLC5A4. SLC5A4 functions as a 73kD glucose sensor in the plasma membrane of cholinergic neurons, skeletal muscle, and smooth muscle. Glucose sensing is critical in the regulation of food intake, blood glucose levels, and enteric reflexes in mammals.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human SLC5A4 (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Diez-Sampedro, A. et al. (2003) A glucose sensor hiding in a family of transporters. Proc. Natl. Acad. Sci. U. S. A. 100: 11753-11758. 2. Scheepers, A. et al. (2004) The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function. JPEN. J. Parenter. Enteral Nutr. 28: 364-371.
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