|Calculated MW||68072 Da|
|Purification||Antisera to USP2 were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Synthetic peptide: Internal domain of human USP2-conjugated to KLH.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Ubiquitin carboxyl-terminal hydrolase 2, 22.214.171.124, 41 kDa ubiquitin-specific protease, Deubiquitinating enzyme 2, Ubiquitin thioesterase 2, Ubiquitin-specific-processing protease 2, USP2, UBP41|
|Target/Specificity||ABD10924 detects an epitope within the internal region of human ubiquitin specific protease 2 (USP2), also known as UBP41. USP2 is a deubiquitinating protease which rescues proteins from the ubiquitin mediated 26S proteasomal pathway. The USP2 gene encodes two splice variants- USP2a and USP2b, with molecular weights of 69kD and 48kD respectively. USP2a deubiquitinates the antiapoptotic proteins fatty acid synthase (FAS) and Mdm2. FAS is overexpressed in the majority of epithelial tumours, including prostate cancer, whilst Mdm2 indicates that USP2 may regulate p53-dependent pathways.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human USP2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Stevenson L.F. et al. (2007) The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2. EMBO J. 26: 976-986. 2. Priolo, C. et al. (2006) The Isopeptidase USP2a Protects Human Prostate Cancer from Apoptosis. Cancer Res. 66: 8625-8632.3. Graner, E. et al. (2004) The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer. Cancer Cell. 5: 253-261.4. Gewies, A. and Grimm, S. (2003) UBP41 is a proapoptotic ubiquitin-specific protease.Cancer Res. 63: 682-688.
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