|Purification||Antisera to rat ribosomal S6 kinase 2 (CT) were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Synthetic peptide corresponding to the C-terminal region of rat ribosomal S6 kinase 2, conjugated to keyhole limpet hemocyanin.|
|Shelf Life||12 months from date of reconstitution.|
|Target/Specificity||ABD10925 recognises ribosomal S6 Kinase 2 (GenBank: EDL96130.1), an 83kDa member of the S6 kinase subfamily of Ser/Thr protein kinases. The kinase is downstream of the extracellular signal-related kinase (ERK)/MAPK cascade and mediates growth-factor and stress induced activation of the transcription factor cAMP response element-binding protein. Ribosomal S6 Kinase 2 has been shown to inhibit G protein-coupled receptors and it’s loss leads to Coffin-Lowry syndrome and nonsyndromic X-linked mental retardation. It is widely expressed, primarily in lung and skeletal muscle.|
|Preservative & Stabilisers||0.09% Sodium Azide; 0.01% Bovine Serum Albumin; 50% Glycerol|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Ribosomal S6 Kinase 2 (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Field, M. et al. (2006) Mutations in the RSK2(RPS6KA3) gene cause Coffin-Lowry syndrome and nonsyndromic X-linked mental retardation.Clin Genet. 70:509-515. 2. Thomas, G. et al. (2005) Ribosomal S6 kinase 2 interacts with and phosphorylates PDZ domain-containing proteins and regulates AMPA receptor transmission.Proc. Nat. Acad. Sci. U S A. 102:15006–15011. 3. Sheffler, D. et al. (2006) p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling.Proc Natl Acad Sci U S A. 103:4717-4722.
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