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Anti-Ribosomal S6 Kinase 2 (C-Terminal) Antibody

Rabbit Anti-Rat Polyclonal Antibody

  • WB - Anti-Ribosomal S6 Kinase 2 (C-Terminal) Antibody  ABD10925
    Western blot of rat hippocampal lysate showing specific immunolabeling of the ~90 kDa RSK2 protein
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Reactivity Rat
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Additional Information
Purification Antisera to rat ribosomal S6 kinase 2 (CT) were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Immunogen Synthetic peptide corresponding to the C-terminal region of rat ribosomal S6 kinase 2, conjugated to keyhole limpet hemocyanin.
Shelf Life 12 months from date of reconstitution.
Target/Specificity ABD10925 recognises ribosomal S6 Kinase 2 (GenBank: EDL96130.1), an 83kDa member of the S6 kinase subfamily of Ser/Thr protein kinases. The kinase is downstream of the extracellular signal-related kinase (ERK)/MAPK cascade and mediates growth-factor and stress induced activation of the transcription factor cAMP response element-binding protein. Ribosomal S6 Kinase 2 has been shown to inhibit G protein-coupled receptors and it’s loss leads to Coffin-Lowry syndrome and nonsyndromic X-linked mental retardation. It is widely expressed, primarily in lung and skeletal muscle.
Preservative & Stabilisers 0.09% Sodium Azide; 0.01% Bovine Serum Albumin; 50% Glycerol
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Ribosomal S6 Kinase 2 (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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1. Field, M. et al. (2006) Mutations in the RSK2(RPS6KA3) gene cause Coffin-Lowry syndrome and nonsyndromic X-linked mental retardation.
Clin Genet. 70:509-515. 2. Thomas, G. et al. (2005) Ribosomal S6 kinase 2 interacts with and phosphorylates PDZ domain-containing proteins and regulates AMPA receptor transmission.
Proc. Nat. Acad. Sci. U S A. 102:15006–15011. 3. Sheffler, D. et al. (2006) p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling.
Proc Natl Acad Sci U S A. 103:4717-4722.

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Cat# ABD10925
(40 western blots)
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