|Calculated MW||28672 Da|
|Purification||Purified IgG prepared by affinity chromatography|
|Immunogen||Synthetic human DKK1 - KLH conjugated.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Dickkopf-related protein 1, Dickkopf-1, Dkk-1, hDkk-1, SK, DKK1|
|Target/Specificity||ABD10926 recognises human Dickkopf (Xenopus laevis) homolog 1 (DKK1), a 35kDa to 50kDa member of the dickkopf family. It is expressed in the placenta, prostate and to a lesser extent, in the colon and spleen. DKK1 is secreted when expressed in 293T cells.DKK1 inhibits Wnt signalling in embryonic development, most likely acting upstream of frizzled. It is also thought to contribute to neoplastic processes, inhibit osteoblast differentiation and is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.|
|Preservative & Stabilisers||0.1% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human DKK1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Krupnik, V. et al. (1999) Functional and structural diversity of the human Dickkopf gene family. Gene. 238:301-13. 2. Fedi, P. et al (1999) Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling. J. Biol. Chem. 274:19465-19472. 3. Niehrs C. (2006) Function and biological roles of the Dickkopf family of Wnt modulators. Oncogene. 25:7469-81.
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