|Calculated MW||79694 Da|
|Purification||Antisera to SLC5A3 were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Synthetic peptide: C-terminal domain of human SLC5A3, conjugated to KLH.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Sodium/myo-inositol cotransporter, Na(+)/myo-inositol cotransporter, Sodium/myo-inositol transporter 1, SMIT1, Solute carrier family 5 member 3, SLC5A3|
|Target/Specificity||ABD10931 detects an epitope within the C-terminal region of sodium-dependent myo-inositol cotransporter-1 (SLC5A3), also known as SMIT-1. SLC5A3 is a membrane associated transporter which is expressed in many human tissues including the brain, kidney and placenta. It is up-regulated in hypertonic conditions and functions in cellular osmoregulation by regulating myo-inositol (MI) uptake. MI is the precursor for phosphatidylinositol and its derivatives, all of which have functions in signal transduction. It is approximately 80kD in size.Up-regulation of SLC5A3 may be associated with an increased risk for bipolar I disorder, and is also thought to be a factor in the pathophysiology of Down syndrome.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human SLC5A3 (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Mallee, J.J. et al. (1997) The structural organization of the human Na+/myo-inositol cotransporter (SLC5A3) gene and characterization of the promoter. Genomics. 46: 459-465.2. Chau, J.F. et al. (2005) Sodium/myo-inositol cotransporter-1 is essential for the development and function of the peripheral nerves. FASEB J. 19: 1887-1889.3. Willmroth, F. et al. (2007) Sodium-myo-inositol co-transporter (SMIT-1) mRNA is increased in neutrophils of patients with bipolar 1 disorder and down-regulated under treatment with mood stabilizers. Int. J. Neuropsychopharmacol. 10: 63-71.
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