|Application ||WB, IHC-F|
|Calculated MW||20730 Da|
|Purification||Antisera to human IL-23 (CT) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||A 14 amino acid peptide from near the carboxy-terminus of human IL-23.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Interleukin-23 subunit alpha, IL-23 subunit alpha, IL-23-A, Interleukin-23 subunit p19, IL-23p19, IL23A, SGRF|
|Target/Specificity||ABD10937 detects an epitope within the C-terminal (CT) domain of human interleukin-23 (IL-23), a 21kD heterodimeric cytokine structurally related to IL-12. IL-23 is composed of a p19 subunit encoded by the IL23A gene, and a p40 subunit of interleukin-12 (IL12B). IL-23 is expressed mainly by activated macrophages and dendritic cells, and plays an important role in bridging innate and adaptive responses.IL-23 activates a subset of T cells called Th17 cells, which are characterised by the production of interleukin-17. The IL-23/IL-17 pathway is essential for the induction and maintenance of brain and joint inflammatory autoimmune diseases, including Guillain Barre Syndrome, Multiple sclerosis and rheumatoid arthritis.|
|Preservative & Stabilisers||0.02% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Interleukin-23 (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Kikly, K. et al. (2006) The IL-23/Th(17) axis: therapeutic targets for autoimmune inflammation.Curr. Opin. Immunol. 18: 670-675.2. Hu, W. et al. (2006) Interleukin 23 in acute inflammatory demyelination of the peripheral nerve.Arch Neurol. 63: 858-864.3. Langrish, C.L. et al. (2004) IL-12 and IL-23: master regulators of innate and adaptive immunity.Immunol. Rev. 202: 96-105.4. Hunter, C.A. (2005) New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. Nat. Rev. Immunol. 5: 521-531.
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