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Anti-Human Interleukin-23 (C-Terminal) Antibody

Rabbit Anti-Human Polyclonal Antibody

  • WB - Anti-Human Interleukin-23 (C-Terminal) Antibody  ABD10937
    Western blot analysis of whole cell lysate form Raji, human Burkitt's lymphoma derived cells probed with Rabbit anti Human Interleukin-23 in the absence (A) or presence (B) of blocking peptide
  • ICC - Anti-Human Interleukin-23 (C-Terminal) Antibody  ABD10937
    Immunocytochemical staining of Raji cells with Rabbit anti Human interleukin-23
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NPF7
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 20730 Da
Additional Information
Other Species M
Purification Antisera to human IL-23 (CT) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen A 14 amino acid peptide from near the carboxy-terminus of human IL-23.
Shelf Life 18 months from date of despatch.
Gene ID 51561
Other Names Interleukin-23 subunit alpha, IL-23 subunit alpha, IL-23-A, Interleukin-23 subunit p19, IL-23p19, IL23A, SGRF
Target/Specificity ABD10937 detects an epitope within the C-terminal (CT) domain of human interleukin-23 (IL-23), a 21kD heterodimeric cytokine structurally related to IL-12. IL-23 is composed of a p19 subunit encoded by the IL23A gene, and a p40 subunit of interleukin-12 (IL12B). IL-23 is expressed mainly by activated macrophages and dendritic cells, and plays an important role in bridging innate and adaptive responses.IL-23 activates a subset of T cells called Th17 cells, which are characterised by the production of interleukin-17. The IL-23/IL-17 pathway is essential for the induction and maintenance of brain and joint inflammatory autoimmune diseases, including Guillain Barre Syndrome, Multiple sclerosis and rheumatoid arthritis.
Preservative & Stabilisers 0.02% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human Interleukin-23 (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Kikly, K. et al. (2006) The IL-23/Th(17) axis: therapeutic targets for autoimmune inflammation.
Curr. Opin. Immunol. 18: 670-675.2. Hu, W. et al. (2006) Interleukin 23 in acute inflammatory demyelination of the peripheral nerve.
Arch Neurol. 63: 858-864.3. Langrish, C.L. et al. (2004) IL-12 and IL-23: master regulators of innate and adaptive immunity.
Immunol. Rev. 202: 96-105.4. Hunter, C.A. (2005) New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions.
Nat. Rev. Immunol. 5: 521-531.

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Cat# ABD10937
(40 western blots)
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