|Calculated MW||27680 Da|
|Purification||Antisera to Caspase-14 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||A 16 amino acid peptide from near the carboxy-terminus of human Caspase-14.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Caspase-14, CASP-14, 3.4.22.-, Caspase-14 subunit p19, Caspase-14 subunit p10, CASP14|
|Target/Specificity||ABD10938 detects an epitope within the C-terminal (CT) region of human caspase-14; a 27kD cysteine protease which is activated by zymogen processing during cellular differentiation. It is highly expressed by keratinocytes and trophoblast cells of the placenta, with lower expression in the choroid plexus, the pigmented layer of the retina, and hair follicles. Expression of the caspase-14 gene has recently been identified in epithelial tumours, including cervical and bladder carcinoma. The biological function of caspase-14 in tumour and normal tissue remains to be classified.|
|Preservative & Stabilisers||0.02% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Caspase-14 (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Park, K. et al. (2006) Expression and characterization of constitutively active human caspase-14.Biochem. Biophys. Res. Commun. 347: 941-948.2. Koenig U. et al. (2005) Aberrant expression of caspase-14 in epithelial tumors.Biochem Biophys Res Commun. 335: 309-313.3. White, L. et al. (2007) Caspase-14: a new player in cytotrophoblast differentiation.Reprod. Biomed. Online. 14: 300-307.
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