|Calculated MW||25298 Da|
|Purification||Antisera to human CTRP5 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||A 15 amino acid peptide from near the centre of human CTRP5.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Complement C1q tumor necrosis factor-related protein 5, C1QTNF5, CTRP5|
|Target/Specificity||ABD10939 detects an epitope within C1q and TNF related protein 5 (CTRP5), also known as C1QTNF5. CTRP5 encodes a novel short chain collagen which is widely expressed with highest expression in the retinal pigment epithelium (RPE) and ciliary epithelium (CE). It is a secretory protein, which associates with membrane type frizzled related protein (MFRP), and may aid the adhesion of basal RPE to Bruch membrane.Mutation to CTRP5 causes it to be retained in the endoplasmic reticulum, and can lead to late-onset retinal degeneration (LORD) and long anterior lens zonules. CTRPs are often highly modified post-translationally, so whereas the predicted molecular weight for CTRP5 is 25kD, ABD10939 detects a single band at 40kD.|
|Preservative & Stabilisers||0.02% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CTRP5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Shu, X. et al. (2006) Disease mechanisms in late-onset retinal macular degeneration associated with mutation in C1QTNF5. Hum. Mol. Genet. 15: 1680-1689.2. Ayyagari, R. et al. (2005) Late-onset macular degeneration and long anterior lens zonules result from a CTRP5 gene mutation. Invest. Ophthalmol. Vis. Sci. 46: 3363-3371.
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