|Calculated MW||29986 Da|
|Purification||Antisera to human Slug were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||13 amino acid peptide sequence near the centre of human Slug.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Zinc finger protein SNAI2, Neural crest transcription factor Slug, Protein snail homolog 2, SNAI2, SLUG, SLUGH|
|Target/Specificity||Rabbit anti-Slug antibody detects Slug, a member of the Snail family of zinc finger transcription factors, whose expression is induced by FGF, BMP, and TGF-ß. Slug is a 29kD transcriptional repressor, which functions by binding to E-box motifs and inhibiting gene expression by recruiting histone deacetylase-1 (HDAC-1).Slug controls the expression of a wide variety of genes including TP53, BRCA2, PUMandCDH1, and has important roles in apoptosis and epithelial-mesenchymal transition. It is also thought to function in neural crest development.Slug expression in breast, oesophageal, and colorectal carcinomas has been correlated with poor prognosis for survival. Rabbit anti-Slug antibody is not cross-reactive with Snail.|
|Preservative & Stabilisers||0.02% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Slug Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Tripathi, M.K. et al. (2005) Regulation of BRCA2 gene expression by the SLUG repressor protein in human breast cells. J. Biol. Chem. 280: 17163-17171.
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