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Anti-BMI-1 Antibody

Rabbit Anti-Human Polyclonal Antibody

  • WB - Anti-BMI-1 Antibody  ABD10944
    Western blot analysis of whole cell lysate from K562 human erythromyeloblastoid cells probed with Rabbit anti Human BMI-1 at 0.5(A), 1(B) and 2(C) ug/ml
  • ICC - Anti-BMI-1 Antibody  ABD10944
    Immunocytochemical staining of K562 cells with Rabbit anti Human BMI-1
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P35226
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 36949 Da
Additional Information
Other Species Rat,M
Purification Antisera to human BMI-1 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen 15 amino acid peptide sequence near the centre of human BMI-1.
Shelf Life 18 months from date of despatch.
Gene ID 100532731;648
Other Names Polycomb complex protein BMI-1, Polycomb group RING finger protein 4, RING finger protein 51, BMI1, PCGF4, RNF51
Target/Specificity Rabbit anti-BMI-1 antibody recognizes 37kDa polycomb complex protein BMI-1, involved in segment specification, cell growth and maintenance, transcriptional regulation and chromatin modification. BMI-1 is a proto-oncogene which cooperates with the myc oncogene to produce B-lymphomas. It is required in the regulation of normal adult and leukaemic stem cells, making BMI-1 a potential target for stem cell proliferation and anti-cancer therapies. BMI-1 represses transcription at the ink4 locus which contains tumour suppressors p16 and p19Arf.BMI-1 is a component of the Polycomb group (PcG) multiprotein PRC1 complex which ubiquitinates histone-2A at lys119, resulting in a heritable change in the ability of chromatin to express genes. BMI-1 is also required to stimulate the E3 ubiquitin ligase activity of RNF2/RING2 within the PRC1 complex.The Notch ligand DLL4 (delta-like protein 4) enhances T cell proliferation, by directly influencing BMI-1 transcription.
Preservative & Stabilisers 0.02% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-BMI-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Raaphorst, F. et al. (2003) Self-renewal of hematopoietic and leukemic stem cells: a central role for the Polycomb-group gene Bmi-1.
Trends Immunol. 10:522-4.2. Alkema, M. et al. (1993) Characterization and chromosomal localization of the human proto-oncogene BMI-1.
Hum. Mol. Genet. 2:1597-1603.3. Lessard, J. et al. (2003) BMI-1 determines the proliferative capacity of normal and leukaemic stem cells.
Nature 423:255-260.

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Cat# ABD10944
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