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Anti-PAK2 (C-Terminal) Antibody

Rabbit Anti-Human Polyclonal Antibody

  • IHC - Anti-PAK2 (C-Terminal) Antibody  ABD10945
    Formalin fixed, paraffin embedded mouse spleen stained with Rabbit anti Human PAK2 following heat mediated antigen retrieval using sodium citrate buffer (pH6.0)
  • WB - Anti-PAK2 (C-Terminal) Antibody  ABD10945
    western blot analysis of whole cell lysate from Jurkat human T-cell leukemia cells probed with Rabbit anti Human PAK2 at 0.5(A) and 1(B) ug/ml
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13177
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 58043 Da
Additional Information
Other Species Rat,M
Purification Antisera to human PAK2 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen 14 amino acid peptide sequence near the carboxy terminus of human PAK2.
Shelf Life 18 months from date of despatch.
Gene ID 5062
Other Names Serine/threonine-protein kinase PAK 2,, Gamma-PAK, PAK65, S6/H4 kinase, p21-activated kinase 2, PAK-2, p58, PAK-2p27, p27, PAK-2p34, p34, C-t-PAK2, PAK2
Target/Specificity ABD10945 recognises p21-activated kinase-2 (PAK2), a ubiquitously expressed, 64kDa, serine/threonine protease found at higher levels in skeletal muscle, ovary, thymus and spleen. p21-activated kinases (PAKs) bind activated Cdc42 and Rac via a Cdc42/Rac interactive binding (CRIB) domain. Group 1 PAK kinases (PAK1, 2 and 3) regulate the activity of an adjacent conserved autoinhibitory domain and are associated with cellular processes, including cytoskeleton rearrangement, apoptosis and MAP kinase signalling. Group 2 PAKs (PAK4, 5, and 6) lack the autoinhibitory domain and are not activated by Cdc42/Rac binding. PAK2 has a cytostatic effect on cells and is activated in response to cellular stresses such hyperosmolarity, serum starvation, contact inhibition and DNA damage from radiation and chemicals. Unlike other PAKs, PAK2 can be activated by proteolytic cleavage to generate a constitutively active fragment, PAK2p34, which induces a cell death response. This induction is thought to be regulated by Rho GTPase-activating protein 10 which inhibits the protein kinase activity of PAK2p34 and causes it to localise to the perinuclear region instead of the nucleus. PAK2 may also play a role in X-linked mental retardation.
Preservative & Stabilisers 0.02% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-PAK2 (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Roig, J. et al. (2001) Cytostatic p21 G protein-activated protein kinase gamma-PAK.
Vitam Horm. 62:167-198.2. Rudel, T. et al. (1997) Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2.
Science. 276:1571-1574.3. Jaffer, Z. et al. (2002) p21-activated kinases: three more join the Pak.
Int. J. Biochem. Cell. Biol. 34:713-717.

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Cat# ABD10945
(40 western blots)
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