|Application ||WB, IHC-P|
|Calculated MW||12029 Da|
|Purification||Antisera to human PEN2 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||13 amino acid peptide sequence near the amino terminus of human PEN2.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Gamma-secretase subunit PEN-2, Presenilin enhancer protein 2, PSENEN, PEN2|
|Target/Specificity||ABD10947 recognises Presenilin enhancer protein 2 (PEN), a 12 kDa member of the PEN2 family and subunit of the gamma-secretase complex. This complex is an endoprotease that cleaves integral membrane proteins. These include Notch receptors and the beta-amyloid precursor protein which is cleaved to form amyloid beta peptide, a major component of the neuritic plaques found in Alzheimer’s disease. The gamma secretase complex consists of nicastrin, the presenilin homodimers and APH1. It is the addition of PEN2, the final stage of gamma secretase maturation that facilitates endoproteolysis of presenilin and confers proteolytic activity. PEN2 expression has been observed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain.|
|Preservative & Stabilisers||0.02% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human PEN2 (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Francis, R. et al. (2002) aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of beta-APP, and presenilin protein accumulation. Dev. Cell 3:85-97.2. Steiner, H. et al. (2002) PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin.J. Biol. Chem. 277: 39062-39065.
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