|Calculated MW||68436 Da|
|Purification||Antisera to human SHP2 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||14 amino acid peptide sequence near the carboxy terminus of human SHP2.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Tyrosine-protein phosphatase non-receptor type 11, 220.127.116.11, Protein-tyrosine phosphatase 1D, PTP-1D, Protein-tyrosine phosphatase 2C, PTP-2C, SH-PTP2, SHP-2, Shp2, SH-PTP3, PTPN11, PTP2C, SHPTP2|
|Target/Specificity||Rabbit anti-SHP2 antibodyecognises src homology 2 domain containing tyrosine phosphatase (SHP2), a 68 kDa member of the protein tyrosine phosphatase family. SHP2 acts downstream of growth factor receptors and cytoplasmic protein tyrosine kinases which transduce signals from cell surface to the nucleus. The recruitment and activation of SHP2 is mediated through the binding of CD172a to its ligand CD47.SHP2 regulates a variety of cellular processes. These include transcription, embryonic development, cell growth, cell migration, differentiation, mitotic cycle, haematopoiesis and oncogenic transformation. As a result, dysregulation of the SHP2 gene has been linked to LEOPARD, Noonan and Noonan-like syndrome as well as acute myeloid leukaemia. SHP2 is ubiquitously expressed, with highest levels found in heart, brain, and skeletal muscle.|
|Preservative & Stabilisers||0.02% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-SHP2 (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Salmond, R. et al. (2006) SHP2 forecast for the immune system: fog gradually clearing.Trends in Immunology. 27:154-160.2. Fujioka, Y. et al. (1996) A Novel Membrane Glycoprotein, SHPS-1, That Binds the SH2-Domain-Containing Protein Tyrosine Phosphatase SHP-2 in Response to Mitogens and Cell Adhesion. Mol Cell Biol. 16:6887-6899.
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