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Anti-SOCS-1 (N-Terminal) Antibody

Rabbit Anti-Human Polyclonal Antibody

  • WB - Anti-SOCS-1 (N-Terminal) Antibody  ABD10949
    Western blot analysis of human spleen lysate probed with Rabbit anti Human SOCS-1 at 1(A), 2(B) and 4(C) ug/ml
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O15524
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 23551 Da
Additional Information
Other Species M,Rat
Purification Antisera to human SOCS1 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen 17 amino acid peptide sequence near the amino terminus of human SOCS1.
Shelf Life 18 months from date of despatch.
Gene ID 8651
Other Names Suppressor of cytokine signaling 1, SOCS-1, JAK-binding protein, JAB, STAT-induced STAT inhibitor 1, SSI-1, Tec-interacting protein 3, TIP-3, SOCS1, SSI1, TIP3
Target/Specificity ABD10949 recognises Suppressor of cytokine signalling 1 (SOCS1), a 24kDa member of the Suppressor of cytokine signalling family. SOCS1 acts downstream of cytokine receptors and plays a role in the negative regulation of cytokine signalling. It acts mainly on the Janus kinase (JAK)/signal transducers and activators of transcription-3 (STAT3) pathway but also inhibits signalling by cytokines such as insulin and toll-like receptors. Furthermore SOCS1 is involved in ubiquitin-dependent protein degradation, plays a role in T cell activation and in the regulation of IL-6, IL-4, IL-12 and IL-15. SOCS1 is expressed ubiquitously and at elevated levels in the spleen, small intestine and peripheral blood leukocytes.
Preservative & Stabilisers 0.02% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-SOCS-1 (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Davey, G. et al. (2006) SOCS1: a potent and multifaceted regulator of cytokines and cell-mediated inflammation.
Tissue Antigens. 67:1-9.2. Rakesh, K. et al. (2005) Controlling cytokine signaling by constitutive inhibitors.
Biochem Pharmacol. 70:649-57.

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Cat# ABD10949
(40 western blots)
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