|Calculated MW||26676 Da|
|Purification||Purified IgG was prepared by affinity chromatography.|
|Immunogen||A 16 amino acid peptide located near the centre of human IL-32.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Interleukin-32, IL-32, Natural killer cells protein 4, Tumor necrosis factor alpha-inducing factor, IL32, NK4, TAIF|
|Target/Specificity||ABD10951 recognises IL-32, a 26 kDa cytokine, thought to play a role in innate and adaptive immune responses. IL-32 is produced by mitogen-activated lymphocytes, interferon-gamma activated epithelial cells and IL-12, IL-18, IL-32-activated NK cells. It is expressed at elevated levels after the activation of T-cells by mitogens or the activation of NK cells by IL-2. IL-32 activates NF-kappa-B and p38 MAPK cytokine signal pathways. TNF-alpha, IL-1beta, IL-6 and 2 C-X-C chemokine family members, all involved in autoimmune and inflammatory diseases, including rheumatoid arthritis are induced by IL-32.|
|Preservative & Stabilisers||0.02% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Interleukin-32 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Conti, P. (2007) Modulation of autoimmunity by the latest interleukins (with special emphasis on IL-32). Autoimmun Rev. 6:131-7.2. Chen, Q. (2006) The newest interleukins: recent additions to the ever-growing cytokine family. Vitam Horm. 74:207-28.3. Kim, S. (2005) Interleukin-32: a cytokine and inducer of TNFalpha. Immunity. 22:131-42.4. Cagnard, N. (2005) Interleukin-32, CCL2, PF4F1 and GFD10 are the only cytokine/chemokine genes differentially expressed by in vitro cultured rheumatoid and osteoarthritis fibroblast-like synoviocytes. Eur Cytokine Netw. 16:289-92.
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