|Calculated MW||129295 Da|
|Purification||Antisera to human CD49b were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Synthetic peptide: Extracellular domain of human CD49b, conjugated to KLH.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Integrin alpha-2, CD49 antigen-like family member B, Collagen receptor, Platelet membrane glycoprotein Ia, GPIa, VLA-2 subunit alpha, CD49b, ITGA2, CD49B|
|Target/Specificity||ABD10956 detects an epitope within the extracellular domain of human CD49b, also known as integrin alpha-2 (ITGA2). CD49b is a 160kD glycoprotein that non-covalently associates with integrin beta 1 (CD29) to form the VLA-2 complex.This complex is involved in cell adhesion and cell-surface mediated signalling, and functions as a cell surface receptor for many types of collagen. Originally identified on activated human T lymphocytes, this complex was subsequently shown to be present on a wide variety of cell types including fibroblasts and platelets. VLA-2 has been linked to cardiovascular disease, cancer development and metastasis. CD49b has been identified on a subset of regulatory T cells which produce interleukin 10 (IL-10).|
|Preservative & Stabilisers||0.1% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD49b Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Charbonnier, L.M. et al. (2006) Immature dendritic cells suppress collagen-induced arthritis by in vivo expansion of CD49b+ regulatory T cells. J. Immunol. 177: 3806-3813. 2. Langsenlehner, U. et al. (2006) Integrin alpha-2 and beta-3 gene polymorphisms and breast cancer risk. Breast Cancer Res Treat. 97: 67-72.1. Nikolopoulos, G.K. et al. (2007) Integrin, alpha 2 gene C807T polymorphism and risk of ischemic stroke: a meta-analysis. Thromb Res. 119: 501-510.
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