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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-Human CD49b Antibody    

Anti-Human CD49b Antibody

Rabbit Anti-Human Polyclonal Antibody

  • IHC - Anti-Human CD49b Antibody  ABD10956
    Staining of formalin fixed, paraffin embedded thymic medulla with Rabbit anti Human CD49b
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P17301
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 129295 Da
Additional Information
Purification Antisera to human CD49b were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen Synthetic peptide: Extracellular domain of human CD49b, conjugated to KLH.
Shelf Life 18 months from date of despatch.
Gene ID 3673
Other Names Integrin alpha-2, CD49 antigen-like family member B, Collagen receptor, Platelet membrane glycoprotein Ia, GPIa, VLA-2 subunit alpha, CD49b, ITGA2, CD49B
Target/Specificity ABD10956 detects an epitope within the extracellular domain of human CD49b, also known as integrin alpha-2 (ITGA2). CD49b is a 160kD glycoprotein that non-covalently associates with integrin beta 1 (CD29) to form the VLA-2 complex.This complex is involved in cell adhesion and cell-surface mediated signalling, and functions as a cell surface receptor for many types of collagen. Originally identified on activated human T lymphocytes, this complex was subsequently shown to be present on a wide variety of cell types including fibroblasts and platelets. VLA-2 has been linked to cardiovascular disease, cancer development and metastasis. CD49b has been identified on a subset of regulatory T cells which produce interleukin 10 (IL-10).
Preservative & Stabilisers 0.1% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human CD49b Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Charbonnier, L.M. et al. (2006) Immature dendritic cells suppress collagen-induced arthritis by in vivo expansion of CD49b+ regulatory T cells.
J. Immunol. 177: 3806-3813. 2. Langsenlehner, U. et al. (2006) Integrin alpha-2 and beta-3 gene polymorphisms and breast cancer risk.
Breast Cancer Res Treat. 97: 67-72.1. Nikolopoulos, G.K. et al. (2007) Integrin, alpha 2 gene C807T polymorphism and risk of ischemic stroke: a meta-analysis.
Thromb Res. 119: 501-510.

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Cat# ABD10956
(40 western blots)
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