|Calculated MW||46742 Da|
|Purification||Antisera to rat GSK3 beta (pSer9) were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Phosphopeptide corresponding to amino acid sequence surrounding phoshorylated seine 9 of rat GSK3 beta.|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Glycogen synthase kinase-3 beta, GSK-3 beta, 220.127.116.11, Factor A, FA, Serine/threonine-protein kinase GSK3B, 18.104.22.168, Gsk3b|
|Target/Specificity||ABD10957 recognises glycogen synthase 3 (GSK3) beta phosphorylated at serine 9. This is a 46 kDa member of the serine/threonine protein kinase family. Two isforms of GSK3 exist, alpha and beta. GSK3 beta is expressed in the testis, thymus, prostate, and ovary as well as being expressed at low levels in lung, brain and kidney tissue.GSK3 beta is involved in many signalling pathways including energy metabolism, body pattern formation and microtubule growth and stability (which aids axon growth). GSK3 beta is also thought to be involved in oncogenesis and the hormonal control of several regulatory proteins including glycogen synthase.Phosphorylation of serine-9 inhibits GSK3 beta function.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3); 50% Glycerol; 0.01% Bovine Serum Albumin;|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-GSK3 beta (pSer9) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Green, J. (2004) Lkb1 and GSK3-beta: kinases at the center and poles of the actionCell Cycle 3:12-14. 2. Papkoff, J. et al. (1998) WNT-1 and HGF regulate GSK3 beta activity and beta-catenin signaling in mammary epithelial cells.Biochem. Biophys. Res. Commun. 247:851-8. 3. Stambolic, V. et al. (1994) Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation.Biochem, J. 303:701-4. 4. Garrido, J. et al. (2007) GSK3 alpha and GSK3 beta are necessary for axon formation.FEBS Lett. 581:1579-86.
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