|Calculated MW||73988 Da|
|Purification||Antisera to synapsin I (pSer 549) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Phosphopeptide corresponding to amino acid sequence surrounding the phosphorylated serine 549 of synapsin I.|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Synapsin-1, Synapsin I, Syn1|
|Target/Specificity||ABD10960 recognises synapsin I, phosphorylated at serine residue 549. It is a 78 kDa member of the synapsin family, expressed in the central and peripheral nervous system. Synapsins coat synaptic vesicles, binding them to the cytoskeleton and are thought to regulate their availability for release. Synapsins are important in brain plasticity, axonogenesis and synaptogenesis. Mutations in the synapsin I gene may be associated with disorders such as X-linked recessive epilepsy associated with variable learning disabilities and behavior disorders.Phosphorylation of serine residue 549 by MAP kinase or cyclin-dependent kinases 1 or 5 is an important part in modulating synaptic vesicle trafficking.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3); 0.01% Bovine Serum Albumin; 50% Glycerol|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Rat Synapsin I (pSer549) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Baldelli, P. et al. (2005) Synapsins and neuroexocytosis: recent views from functional studies on synapsin null mutant mice.Arch. Ital. Biol. 143:113-26. 2. Garcia, C. et al. (2004) Identification of a mutation in synapsin I, a synaptic vesicle protein, in a family with epilepsy. J. Med. Genet. 41:183-187.
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