|Application ||WB, E, IP|
|Calculated MW||47077 Da|
|Purification||Antisera to cyclin E were raised by repeated immunisations of rabbits with highly purified antigen.|
|Immunogen||Full length synthetic polypeptide corresponding to the human gene sequence of cyclin E.|
|Shelf Life||18 months from date of despatch.|
|Other Names||G1/S-specific cyclin-E1, CCNE1, CCNE|
|Target/Specificity||ABD10963 detects cyclin E, a nuclear protein which is the regulatory subunit of cyclin dependent kinase 2 (Cdk2), and controls S phase entry in cells. Cyclin E follows a cyclic pattern of expression during the cell cycle, with highest expression at the G1-S boundary. Although cyclin E has an important physiological role in normal cell division, recent reports suggest this function is redundant, and its key functions occur as cells exit quiescence, and in endoreduplication. Cyclin E is tightly regulated during normal cell cycles, but is often deregulated in carcinomas, lymphoma, and leukaemia.|
|Preservative & Stabilisers||0.01% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Cyclin E Antibody (Serum) is for research use only and not for use in diagnostic or therapeutic procedures.|
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