|Application ||WB, IHC-P, IHC-F, E|
|Calculated MW||86943 Da|
|Purification||Antisera to human amyloid precursor protein were raised by repeated immunisations of goats with highly purified antigen.|
|Immunogen||Synthetic peptide corresponding to the amino acid sequence 44-63 of human amyloid precursor protein.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Amyloid beta A4 protein, ABPP, APPI, APP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, PreA4, Protease nexin-II, PN-II, N-APP, Soluble APP-alpha, S-APP-alpha, Soluble APP-beta, S-APP-beta, C99, Beta-amyloid protein 42, Beta-APP42, Beta-amyloid protein 40, Beta-APP40, C83, P3(42), P3(40), C80, Gamma-secretase C-terminal fragment 59, Amyloid intracellular domain 59, AICD-59, AID(59), Gamma-CTF(59), Gamma-secretase C-terminal fragment 57, Amyloid intracellular domain 57, AICD-57, AID(57), Gamma-CTF(57), Gamma-secretase C-terminal fragment 50, Amyloid intracellular domain 50, AICD-50, AID(50), Gamma-CTF(50), C31, APP, A4, AD1|
|Target/Specificity||ABD10968 recognises amyloid precursor protein (APP), a 130 kDa member of the APP family, expressed in adult brain. It is a cell surface kinesin I membrane receptor which regulates the axonal transport of beta-secretase and presenilin 1.In Alzheimer's disease processing of APP by beta-secretase gives rise to amyloidogenic 42 AA beta amyloid protein that is found in senile plaques and vessels. APP binds components of the extracellular matrix such as heparin and collagen I and IV, regulating neurite growth and is also involved in neuronal adhesion, cell mobility and axonogenesis. Through it’s binding to APBB1/Tip60, APP plays a role in the regulation of transcription. APP also inhibits Notch signaling through it’s interaction with NUMB.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Amyloid Precursor Protein (aa44-63) Antibody (Serum) is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
1. Venezia, V. (2007) Amyloid precursor protein and presenilin involvement in cell signaling. Neurodegener. Dis. 4:101-11.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.