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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-Cholesterol 24-Hydroxylase (C-Terminal) Antibody (Serum)   

Anti-Cholesterol 24-Hydroxylase (C-Terminal) Antibody (Serum)

Goat Anti-Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y6A2
Reactivity Human
Host Goat
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 56821 Da
Additional Information
Purification Antisera to cholesterol 24-hydroxylase (CT) were raised by repeated immunisations of goats with highly purified antigen.
Immunogen Synthetic peptide corresponding to amino acid sequence 254-270 of human cholesterol 24-hydroxylase protein.
Shelf Life 18 months from date of despatch.
Gene ID 10858
Other Names Cholesterol 24-hydroxylase, CH24H,, Cytochrome P450 46A1, CYP46A1, CYP46
Target/Specificity ABD10969 recognises cholesterol 24-hydroxylase (CYP46A1), a 58 kDa member of the Cytochrome P450 family, expressed in the brain. CYP46A1 converts cholesterol into the biologically active oxysterol and 24(S)-hydroxycholesterol, in the first step of the enzymatic degradation of cholesterol in the brain. CYP46A1 is also thought to play a role in the metabolism of neurosteroids and drugs that can cross the blood-brain barrier and are targeted to the central nervous system.P450 enzymes are divided into two groups: steroidogenic and xenobiotic. The latter group is comprised of three families 1, 2 and 3. The xenobiotic p450's are involved in most oxidative drug metabolism. Work in this area is ongoing but studies suggest that all known drug metabolism is mediated by family members: CYP3A, CYP2D6, CYP1A2, CYP2C9/10, CYP2C19 and CYP2E1.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Cholesterol 24-Hydroxylase (C-Terminal) Antibody (Serum) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Pikuleva IA. (2006) Cytochrome P450s and cholesterol homeostasis.
Pharmacol Ther. 112:761-73. 2. Mast, N. et al. (2003) Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain.
Biochemistry. 42:14284-14292. 3. Ng, P. et al. (2003) Production of inhibitory polyclonal antibodies against cytochrome P450s.
Drug Metabol. Pharmacokin. 18(3):163-172.

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Cat# ABD10969
(40 western blots)
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