|Purification||Antisera to 5-hydroxymethyluridine were raised by repeated immunisations of goats with highly purified antigen.|
|Shelf Life||18 months from date of despatch.|
|Target/Specificity||ABD10971 recognises 5-hydroxymethyluridine, which is created by the oxidation of thymine by ionising radiation or reactive oxygen species. This oxidation causes changes in gene expression, mutations and chromosomal instability all of which play a role in cancer, autoimmune disease and aging. 5-hydroxymethyluridine is a potential biomarker for female breast, colon and rectal cancers, being present at elevated levels, possibly due to impaired DNA repair mechanisms.|
|Preservative & Stabilisers||0.1% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-5-Hydroxymethyluridine Antibody (Serum) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Cooney, R. et al. (2001) Association of tocopherols with circulating autoantibody levels against an oxidized DNA nucleoside in humans. Free. Radic. Biol. Med. 31:460-8. 2. Frenkel, K. et al. (1998) Serum autoantibodies recognizing 5-hydroxymethyl-2'-doxyuridine, an oxidized DNA base, as biomarkers of cancer risk in women. Cancer. Epidemiol. Biomarkers Prev. 7:49–57.
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