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>   home   >   Products   >   Primary Antibodies   >   Anti-5-Hydroxymethyluridine Antibody (Serum)   

Anti-5-Hydroxymethyluridine Antibody (Serum)

Goat Anti-Human Polyclonal Antibody

     
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
E
Reactivity Human
Host Goat
Clonality Polyclonal
Isotype Polyclonal IgG
Additional Information
Purification Antisera to 5-hydroxymethyluridine were raised by repeated immunisations of goats with highly purified antigen.
Immunogen 5-hydroxymethyluridine
Shelf Life 18 months from date of despatch.
Target/Specificity ABD10971 recognises 5-hydroxymethyluridine, which is created by the oxidation of thymine by ionising radiation or reactive oxygen species. This oxidation causes changes in gene expression, mutations and chromosomal instability all of which play a role in cancer, autoimmune disease and aging. 5-hydroxymethyluridine is a potential biomarker for female breast, colon and rectal cancers, being present at elevated levels, possibly due to impaired DNA repair mechanisms.
Preservative & Stabilisers 0.1% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-5-Hydroxymethyluridine Antibody (Serum) is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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References

1. Cooney, R. et al. (2001) Association of tocopherols with circulating autoantibody levels against an oxidized DNA nucleoside in humans.
Free. Radic. Biol. Med. 31:460-8. 2. Frenkel, K. et al. (1998) Serum autoantibodies recognizing 5-hydroxymethyl-2'-doxyuridine, an oxidized DNA base, as biomarkers of cancer risk in women.
Cancer. Epidemiol. Biomarkers Prev. 7:49–57.

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Cat# ABD10971
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