|Application ||WB, E, IP|
|Calculated MW||33304 Da|
|Purification||Antisera to Cdk5 were raised by repeated immunisations of rabbits with highly purified antigen.|
|Immunogen||Peptide corresponding to C-terminus of human Cdk5 conjugated to Keyhole Limpet Hemocyanin (KLH).|
|Shelf Life||18 months from date of despatch.|
|Other Names||Cyclin-dependent-like kinase 5, 220.127.116.11, Cell division protein kinase 5, Serine/threonine-protein kinase PSSALRE, Tau protein kinase II catalytic subunit, TPKII catalytic subunit, CDK5, CDKN5|
|Target/Specificity||Rabbit anti-Cdk5 antibody detects human cyclin dependent kinase 5 (Cdk5), a proline-directed serine/threonine protein kinase that unlike most Cdks does not function in cell cycle control, and is not regulated by cyclins. Instead, it requires the association p35 or p39 for its kinase activity, resulting in a master regulator of neuronal functions, with roles in neuronal survival and migration, neurotransmitter release and axon guidance.Cdk5 is ubiquitously expressed, but expression and activity is highest in post mitotic neurones, where p35 and p39 are highly expressed. Deregulation of this kinase is neurotoxic and might contribute to the pathogenesis of Alzheimer's disease and other neurodegenerative disorders.|
|Preservative & Stabilisers||0.01% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Cdk5 (C-Terminal) Antibody (Serum) is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Cheung, Z.H. et al. (2006) Synaptic roles of Cdk5: implications in higher cognitive functions and neurodegenerative diseases.Neuron. 50 (1): 13-8.2. Pareek, T.K. & Kulkarni, A.B. (2006) Cdk5: a new player in pain signaling.Cell Cycle. 5 (6): 585-8.3. Cruz, J.C. & Tsai, L.H. (2004) Cdk5 deregulation in the pathogenesis of Alzheimer's disease.Trends Mol Med. 10 (9): 452-8.
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