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Rabbit Anti-Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P35396 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Polyclonal IgG |
| Calculated MW | 49715 Da |
| Purification | Antisera to PPAR delta were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared from whole serum by affinity chromatography. |
|---|---|
| Immunogen | Syntetic peptide corresponding to amino acids 1-14 of mouse PPAR delta. |
| Shelf Life | 18 months from date of despatch. |
| Gene ID | 19015 |
| Other Names | Peroxisome proliferator-activated receptor delta, PPAR-delta, Nuclear hormone receptor 1, NUC1, Nuclear receptor subfamily 1 group C member 2, Peroxisome proliferator-activated receptor beta, PPAR-beta, Ppard, Nr1c2, Pparb |
| Target/Specificity | ABD10976 detects peroxisome proliferator-activated receptor, delta (PPARD), a member of the nuclear hormone receptor subfamily. Upon activation, PPARD forms heterodimers with retinoid X receptors (RXRs), and functions to regulate transcription of specific gene sequences. PPARD controls genes involved in lipid metabolism, and enhances fatty acid catabolism and energy uncoupling in adipose tissue and skeletal muscle. PPARD has also been implicated in the proliferation and differentiation of preadipocytes, enterocytes, keratinocytes and the placenta.PPARD agonists could be used therapeutically to target multiple components of the metabolic syndrome, including insulin resistance, hyperglycemia, dyslipidemia, and atherosclerosis. |
| Preservative & Stabilisers | 0.09% Sodium Azide (NaN3) |
| Storage | Store at +4℃ or at -20 ℃. |
| Precautions | Anti-PPAR delta (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
References
1. Luquet, S. et al. (2005) Roles of PPAR delta in lipid absorption and metabolism: a new target for the treatment of type 2 diabetes.Biochim. Biophys. Acta. 1740: 313-317.2. Barish, G.D.et al. (2006) PPAR delta: a dagger in the heart of the metabolic syndrome.J. Clin. Invest. 116: 590-597.3. Grimaldi, P.A. (2005) Regulatory role of peroxisome proliferator-activated receptor delta (PPAR delta) in muscle metabolism. A new target for metabolic syndrome treatment?Biochimie. 87: 5-8.
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