|Calculated MW||69947 Da|
|Purification||Antisera to rat GABA transporter 3 (CT) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Synthetic peptide corresponding to the C-terminal region of rat GABA transporter 3.|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Sodium- and chloride-dependent GABA transporter 3, GAT-3, Solute carrier family 6 member 11, Slc6a11, Gabt3, Gat-3, Gat-b|
|Target/Specificity||ABD10983 recognises an epitope within the C-terminal region (CT) of rat GABA transporter 3, otherwise known as GAT-3, a 67kDa high-affinity Na+/Cl- dependent plasma membrane transporter and member of the sodium: neurotransmitter symporter (SNF) family, expressed in the cerebral cortex and retina.GAT-3 is one of a group of proteins involved in the regulation of GABAergic synaptic neurotransmission, through the uptake and release of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter of the mammalian central nervous system, which must be maintained at the correct level to ensure successful synaptic transmission. Further GABA transporter genes identified are GAT-1, GAT-2 and GAT-4, and many studies have linked neurotransmitter transporters with neurological disorders, including epilepsy and ischemia.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3); 0.01% Bovine Serum Albumin; 50% Glycerol|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Rat GABA Transporter 3 (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Conti, F. et al. (2004) GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications.Brain Res. Rev. 45: 196-212.2. Allen, N.J. et al. (2004) Reversal or reduction of glutamate and GABA transport in CNS pathology and therapy.Eur. J. Physiol. 449: 132-142.
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