|Calculated MW||111534 Da|
|Purification||Antisera to GABAB receptor 1 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.|
|Immunogen||Synthetic phosphopeptide corresponding to an amino acid sequence within GABAB receptor 1, which includes phosphorylated Ser923.|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Gamma-aminobutyric acid type B receptor subunit 1, GABA-B receptor 1, GABA-B-R1, GABA-BR1, GABABR1, Gb1, Gabbr1|
|Target/Specificity||ABD10985 specifically recognises the 102kDa transmembrane gamma-aminobutyric acid B (GABAB) receptor 1 (GABR1), when phosphorylated at Ser923. GABAB receptors are heterodimeric G-protein coupled receptors which are important mediators of slow neuronal inhibition in the mammalian central nervous system. The functional expression of GABAB receptors on plasma membranes is dependent upon the co-expression of GABR1 and GABR2 (gamma-aminobutyric acid B (GABAB) receptor 2). Phosphorylation of GABR1 at the Ser923 site may be an important factor in the regulation of GABAB receptor function. Abnormalities in the expression or function of GABAB receptors have become a focus area in studies of temporal lobe epilepsy (TLE).|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3); 0.01% Bovine Serum Albumin; 50% Glycerol|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Rat GABA B Receptor 1 (pSer923) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Bowery, N.G. et al. (2002) International Union of Pharmacology XXXIII. Mammalian gamma-aminobutyric acidB receptors: structure and function.Pharmacol. Rev. 54: 247-264.
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