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>   home   >   Products   >   Primary Antibodies   >   Anti-Rat GABA B Receptor 2 (pSer783) Antibody    

Anti-Rat GABA B Receptor 2 (pSer783) Antibody

Rabbit Anti-Rat Polyclonal Antibody

  • WB - Anti-Rat GABA B Receptor 2 (pSer783) Antibody  ABD10986
    Western blot of a rat synaptic membrane showing phosphospecific immunolabeling of the ~102 kDa GABAB R2 protein phosphorylated at Ser783
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O88871
Reactivity Rat
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 105751 Da
Additional Information
Purification Antisera to GABAB receptor 2 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Immunogen Synthetic phosphopeptide corresponding to an amino acid sequence within GABAB receptor 2, which includes phosphorylated Ser783.
Shelf Life 12 months from date of reconstitution.
Gene ID 83633
Other Names Gamma-aminobutyric acid type B receptor subunit 2, GABA-B receptor 2, GABA-B-R2, GABA-BR2, GABABR2, Gb2, G-protein coupled receptor 51, Gabbr2, Gpr51
Target/Specificity ABD10986 specifically recognises the 102kDa transmembrane gamma-aminobutyric acid B (GABAB) receptor 2 (GABR2), when phosphorylated at Ser783. GABAB receptors are heterodimeric G-protein coupled receptors which are important mediators of slow neuronal inhibition in the mammalian central nervous system. The functional expression of GABAB receptors on plasma membranes is dependent upon the co-expression of GABR1 (gamma-aminobutyric acid B (GABAB) receptor 1) and GABR2. Studies have shown that the phosphorylation of GABR2 at the Ser783 site, by AMPK (5’AMP-activated protein kinase), is vital for enhancing the survival of neurons following ischemic brain injury.
Preservative & Stabilisers 0.09% Sodium Azide (NaN3); 0.01% Bovine Serum Albumin; 50% Glycerol
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Rat GABA B Receptor 2 (pSer783) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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1. Kuramoto, N. et al. (2012) Dephosphorylation of endogenous GABA(B) receptor R2 subunit and AMPK a subunits which were measured by in vitro method using transfer membrane.
Neurochem Int. pii: S0197-0186(12)00393-2.1. Bowery, N.G. et al. (2002) International Union of Pharmacology XXXIII. Mammalian gamma-aminobutyric acidB receptors: structure and function.
Pharmacol. Rev. 54: 247-264.

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Cat# ABD10986
(40 western blots)
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