|Application ||WB, IF|
|Calculated MW||105751 Da|
|Purification||Antisera to GABAB receptor 2 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.|
|Immunogen||Synthetic phosphopeptide corresponding to an amino acid sequence within GABAB receptor 2, which includes phosphorylated Ser783.|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Gamma-aminobutyric acid type B receptor subunit 2, GABA-B receptor 2, GABA-B-R2, GABA-BR2, GABABR2, Gb2, G-protein coupled receptor 51, Gabbr2, Gpr51|
|Target/Specificity||ABD10986 specifically recognises the 102kDa transmembrane gamma-aminobutyric acid B (GABAB) receptor 2 (GABR2), when phosphorylated at Ser783. GABAB receptors are heterodimeric G-protein coupled receptors which are important mediators of slow neuronal inhibition in the mammalian central nervous system. The functional expression of GABAB receptors on plasma membranes is dependent upon the co-expression of GABR1 (gamma-aminobutyric acid B (GABAB) receptor 1) and GABR2. Studies have shown that the phosphorylation of GABR2 at the Ser783 site, by AMPK (5’AMP-activated protein kinase), is vital for enhancing the survival of neurons following ischemic brain injury.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3); 0.01% Bovine Serum Albumin; 50% Glycerol|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Rat GABA B Receptor 2 (pSer783) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Kuramoto, N. et al. (2012) Dephosphorylation of endogenous GABA(B) receptor R2 subunit and AMPK a subunits which were measured by in vitro method using transfer membrane.Neurochem Int. pii: S0197-0186(12)00393-2.1. Bowery, N.G. et al. (2002) International Union of Pharmacology XXXIII. Mammalian gamma-aminobutyric acidB receptors: structure and function.Pharmacol. Rev. 54: 247-264.
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