|Calculated MW||68291 Da|
|Purification||Antisera to PLK1 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.|
|Immunogen||Synthetic phospeptide corresponding to an amino acid sequence within PLK1, which includes phosphorylated Thr210.|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Serine/threonine-protein kinase PLK1, 220.127.116.11, Polo-like kinase 1, PLK-1, Plk1, Plk|
|Target/Specificity||ABD10990 specifically recognises the 66kDa serine/threonine kinase, PLK1 (polo-like kinase 1), when phosphorylated at Thr210.PLK1 is a member of a group of polo-like kinases which play essential roles in the progression of mitosis. PLK1 has been implicated in various stages of mitosis, including promotion through the activation of cyclin B1/Cdk (mitosis promoting factor), the formation of functional mitotic bipolar spindles, and the maturation of centrosomes. The timing at which PLK1 phosphorylation occurs at Ser137 and Thr210 sites, may act as a regulator of PLK1 function through the mitotic cycle.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3); 0.01% Bovine Serum Albumin; 50% Glycerol|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-PLK1 (pThr210) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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