|Calculated MW||96696 Da|
|Purification||Antisera to human brain glycogen phosphorylase were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Synthetic peptide: internal domain of human brain glycogen phosphorylase, conjugated to Keyhole Limpet Hemocyanin.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Glycogen phosphorylase, brain form, 220.127.116.11, PYGB|
|Target/Specificity||Rabbit anti-Human glycogen phosphorylase BB antibody detects brain glycogen phosphorylase, a regulatory enzyme which catalyses the rate-determining step in glycogen degradation. Mammalian glycogen phosphorylase is found as three major isozymes including muscle (GPMM), liver (GPLL), and brain (GPBB), which can be distinguished by their structural and functional properties as well as by the tissues in which they are expressed. GPBB is thought to function in the release of emergency glucose during stress, and in embryogenesis where it is the predominant isozyme. GPBB is also expressed in the early stages of gastric and colorectal cancers.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Glycogen Phosphorylase BB Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Holmes, A.P. et al. (2014) Glycogen metabolism protects against metabolic insult to preserve carotid body function during glucose deprivation.J Physiol. 592 (Pt 20): 4493-506.1. Tashima, S. et al. (2000) Expression of brain-type glycogen phosphorylase is a potentially novel early biomarker in the carcinogenesis of human colorectal carcinomas.Am J Gastroenterol. 95 (1): 255-63.
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