|Calculated MW||152271 Da|
|Purification||Antisera to human CD136 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Synthetic peptide: internal domain of human CD136, conjugated to keyhole limpet hemocyanin.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Macrophage-stimulating protein receptor, MSP receptor, 22.214.171.124, CDw136, Protein-tyrosine kinase 8, p185-Ron, CD136, Macrophage-stimulating protein receptor alpha chain, Macrophage-stimulating protein receptor beta chain, MST1R, PTK8, RON|
|Target/Specificity||Rabbit anti-Human CD136 antibody detects CD136, a receptor tyrosine kinase also known as Macrophage stimulating 1 receptor (MST1R) and RON (Recepteur d’origine nantais). CD136 is a member of the MET proto-oncogene family, and is the receptor for macrophage-stimulating protein (MSP), a multifunctional cytokine that regulates cell adhesion, motility, growth, and survival. CD136 is a disulfide-linked ~180 kDa heterodimer composed of a 40 kDa alpha chain and a 150 kDa beta chain, and is mainly expressed in cells of epithelial origin. In immune cells CD136 expression is restricted to certain types of tissue macrophages, and its activation is critical in modulating macrophage activities and preventing an excessive inflammatory response. CD136 is also required for embryonic development. CD136 expression is significantly altered in several primary human cancers including those of the breast and colon.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD136 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Wang, M.H. et al. (2002) Macrophage-stimulating protein and RON receptor tyrosine kinase: potential regulators of macrophage inflammatory activities.Scand J Immunol. 56 (6): 545-53.
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