|Calculated MW||87713 Da|
|Purification||Antisera to FAP alpha were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Synthetic peptide: extracellular domain of human FAP alpha, conjugated to keyhole limpet hemocyanin.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Prolyl endopeptidase FAP, 220.127.116.11, 170 kDa melanoma membrane-bound gelatinase, Dipeptidyl peptidase FAP, 18.104.22.168, Fibroblast activation protein alpha, FAPalpha, Serine integral membrane protease, SIMP, Surface-expressed protease, Seprase, Antiplasmin-cleaving enzyme FAP, soluble form, APCE, 22.214.171.124, 3.4.21.-, 126.96.36.199, FAP (HGNC:3590)|
|Target/Specificity||ABD10996 detects fibroblast activation protein alpha (FAP alpha), a type II membrane protein belonging to the serine protease family. FAP alpha is upregulated on activated fibroblasts in response to wounding, and may also be involved in epithelial-mesenchymal interactions during development and tissue repair.Active FAP alpha is a 170kD homodimeric protein which can also exist as a soluble form. FAP alpha can also form heterodimeric complexes with CD26 (DPP4), and these proteins may function co-ordinately to modulate the growth, differentiation, adhesion and metastasis of tumour cells.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human FAP alpha Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Kelly, T. (2005) Fibroblast activation protein-alpha and dipeptidyl peptidase IV (CD26): cell-surface proteases that activate cell signaling and are potential targets for cancer therapy. Drug Resist. Updat. 8: 51-58.
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