|Calculated MW||123968 Da|
|Purification||Antisera to human PDGF receptor beta were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Synthetic peptide corresponding to the extracellular domain of human PDGF receptor beta, conjugated to Keyhole Limpet Hemocyanin.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Platelet-derived growth factor receptor beta, PDGF-R-beta, PDGFR-beta, 220.127.116.11, Beta platelet-derived growth factor receptor, Beta-type platelet-derived growth factor receptor, CD140 antigen-like family member B, Platelet-derived growth factor receptor 1, PDGFR-1, CD140b, PDGFRB, PDGFR, PDGFR1|
|Target/Specificity||Rabbit anti-Human CD140b antibody recognizes platelet derived growth factor receptor beta (PDGFRβ), a cell surface tyrosine kinase receptor for platelet-derived growth factor BB. Upon ligand binding PDGFRβ forms homodimers, or heterodimers with PDGFRα, resulting in autophosphorylation. Activated PDGFRs control cell proliferation, migration and survival in mesenchymal cells. CD140b is expressed by non-reticular stromal cells in the bone marrow (Rasiniet al.2013)CD140b has been shown to be important in the recruitment of fibroblasts and pericytes in wound healing.|
|Preservative & Stabilisers||0.1% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD140b Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Rasini, V. et al. (2013) Mesenchymal stromal/stem cells markers in the human bone marrow.Cytotherapy. pii: S1465-3249(12)00038-2.
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