|Application ||WB, E|
|Calculated MW||89091 Da|
|Purification||Antisera to human iASPP were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Synthetic peptide corresponding amino acids 780-797 of human iASPP (isoform 1) protein.|
|Shelf Life||18 months from date of despatch.|
|Other Names||RelA-associated inhibitor, Inhibitor of ASPP protein, Protein iASPP, NFkB-interacting protein 1, PPP1R13B-like protein, PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI|
|Target/Specificity||Rabbit anti-Human iASPP antibody detects human inhibitor of apoptosis stimulating protein of p53 (iASPP), which plays a central role in regulation of apoptosis and transcription via its interaction with NFkB and p53 proteins. At present, the iASPP gene is thought to encode three isoforms; isoform 1 is predominantly located in the cytoplasm, whilst isoforms 2 and 3 are nuclear proteins. iASPP is highly expressed in the heart, placenta and prostate.iASPP has been shown to have oncogenic properties in human breast carcinomas.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human iASPP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Zhang, X. et al. (2007) Identification of a novel isoform of iASPP and its interaction with p53. J. Mol. Biol. 368: 1162-1171.
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