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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-Human Heat Shock Protein 90 alpha Antibody    

Anti-Human Heat Shock Protein 90 alpha Antibody

Rabbit Anti-Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P07900
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 84660 Da
Additional Information
Purification Antisera to human heat shock protein 90 alpha were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Immunogen Synthetic peptide corresponding to amino acids 289-300 of human heat shock protein 90 alpha.
Shelf Life 18 months from date of despatch.
Gene ID 3320
Other Names Heat shock protein HSP 90-alpha, Heat shock 86 kDa, HSP 86, HSP86, Lipopolysaccharide-associated protein 2, LAP-2, LPS-associated protein 2, Renal carcinoma antigen NY-REN-38, HSP90AA1, HSP90A, HSPC1, HSPCA
Target/Specificity ABD11005 detects human heat shock protein 90 alpha (HSP90a), one of two HSP90 isoforms together with HSP90b. These isoforms are encoded by different genes and under normal conditions assist the folding of newly synthesised proteins, and are also important in cellular processes such as hormone signalling and cell cycle control. In response to mutation or environmental stress, HSP90 expression is upregulated as part of the heat shock response, and function to maintain newly destabilised proteins in a folding competent state. HSP90 can also affect the epigenetic state at specific loci, leading to phenotype modulation.Induction of HSP90a by c-Myc may control the activity of multiple signal pathways involved in cellular transformation.
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human Heat Shock Protein 90 alpha Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Teng, S.C. et al. (2004) Direct activation of HSP90A transcription by c-Myc contributes to c-Myc-induced transformation.
J. Biol. Chem. 279: 14649-14655. 2. Chen, W.S. et al. (2013) Secreted Heat Shock Protein 90a (HSP90a) Induces Nuclear Factor-?B-mediated TCF12 Protein Expression to Down-regulate E-cadherin and to Enhance Colorectal Cancer Cell Migration and Invasion.
J Biol Chem. 288: 9001-10.

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Cat# ABD11005
(40 western blots)
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