|Calculated MW||53555 Da|
|Purification||Antisera to 5-HT7 receptor (CT) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Synthetic peptide C-terminal regoin of human 5-HT7 receptor, conjugated to Keyhole Limpet Hemocyanin (KLH).|
|Shelf Life||18 months from date of despatch.|
|Other Names||5-hydroxytryptamine receptor 7, 5-HT-7, 5-HT7, 5-HT-X, Serotonin receptor 7, HTR7|
|Target/Specificity||ABD11007 detects an epitope within the C-terminal of the serotonin (5-hydroxytryptamine, 5-HT) receptor 5-HT7, which belongs to the G-protein coupled receptor superfamily. Serotonin is a neurotransmitter and vasoactive amine which is thought to play a role in various cognitive and behavioural functions including pain, appetite, mood and sleep. Signalling through 5-HT7 has several effects, including regulation of the circadian rhythm and mediation of smooth-muscle relaxation in the vasculature and gastrointestinal tract. Signalling though 5-HT7 has also been shown to contribute to early T-cell activation.5-HT7 has been implicated in depression, autism, and other neuropsychiatric disorders.|
|Preservative & Stabilisers||0.1% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human 5-HT7 Receptor (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Kobe, F. et al. (2012) 5-HT7R/G12 Signaling Regulates Neuronal Morphology and Function in an Age-Dependent Manner.J Neurosci. 32: 2915-30. 2. Renner, U. et al. (2012) Heterodimerization of serotonin receptors 5-HT1A and 5-HT7 differentially regulates receptor signalling and trafficking.J Cell Sci. 125 (Pt 10): 2486-99.1. León-Ponte, M. et al. (2007) Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT7 receptor.Blood. 109 (8): 3139-46.
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