|Calculated MW||53555 Da|
|Purification||Antisera to 5-HT7 receptor (NT) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Synthetic peptide: N-terminal domain of human 5-HT7 receptor, conjugated to Keyhole Limpet Hemocyanin (KLH).|
|Shelf Life||18 months from date of despatch.|
|Other Names||5-hydroxytryptamine receptor 7, 5-HT-7, 5-HT7, 5-HT-X, Serotonin receptor 7, HTR7|
|Target/Specificity||ABD11008 detects an epitope within the N-terminal of the serotonin (5-hydroxytryptamine, 5-HT) receptor 5-HT7, which belongs to the G-protein coupled receptor superfamily. Serotonin is a neurotransmitter and vasoactive amine which is thought to play a role in various cognitive and behavioural functions including pain, appetite, mood and sleep. Signalling through 5-HT7 has several effects, including regulation of the circadian rhythm and mediation of smooth-muscle relaxation in the vasculature and gastrointestinal tract. Signalling though 5-HT7 has also been shown to contribute to early T-cell activation. 5-HT7 has been implicated in depression, autism, and other neuropsychiatric disorders.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human 5-HT7 Receptor (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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