|Calculated MW||44411 Da|
|Purification||Antisera to BRS-3 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Synthetic peptide: 1st cytoplasmic domain of human BRS-3, conjugated to Keyhole Limpet Hemocyanin (KLH).|
|Shelf Life||18 months from date of despatch.|
|Other Names||Bombesin receptor subtype-3, BRS-3, BRS3|
|Target/Specificity||ABD11009 detects bombesin-like receptor-3 (BRS-3), a heptahelical G protein-coupled receptor. BRS-3 is thought to function as a receptor for bombesin-like peptides; which modulate smooth-muscle contraction, exocrine and endocrine processes, metabolism, and behaviour. BRS-3 is thought to be particularly important in regulating obesity and metabolic control of insulin and glucose. BRS-3 expression in secondary spermatocytes suggests BRS-3 has a role in sperm cell division, maturation, or function. BRS-3 could also serve as a potential therapeutic target in human lung carcinoma.|
|Preservative & Stabilisers||0.01% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human BRS-3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Ryan, R.R. et al. (1998) Pharmacology and intracellular signaling mechanisms of the native human orphan receptor BRS-3 in lung cancer cells. J. Pharmacol. Exp. Ther. 287: 366-380.
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