|Calculated MW||57108 Da|
|Purification||Antisera to human SGK3 (CT) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Synthetic peptide: C-terminal domain of human SGK3, conjugated to Keyhole Limpet Hemocyanin (KLH).|
|Shelf Life||18 months from date of despatch.|
|Other Names||Serine/threonine-protein kinase Sgk3, 188.8.131.52, Cytokine-independent survival kinase, Serum/glucocorticoid-regulated kinase 3, Serum/glucocorticoid-regulated kinase-like, SGK3, CISK, SGKL|
|Target/Specificity||ABD11012 detects Serum and glucocorticoid-regulated kinase 3 (SGK3), also known as cytokine-independent survival kinase (CISK). SGK3 is a member of the serine/threonine protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain that targets the protein to endosomes. SGK3 is activated by the phosphatidylinositol 3'-kinase (PI3K) pathway, and plays a critical role in the hair cycle, functioning to negatively regulate PI3K signalling in hair follicle development and homeostasis. SGK3 also has a role in neutral amino acid transport and activation of potassium and chloride channels.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human SGK3 (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Alonso, L. et al. (2005) Sgk3 links growth factor signaling to maintenance of progenitor cells in the hair follicle.J. Cell. Biol. 170: 559-570.
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