|Application ||WB, E|
|Calculated MW||22229 Da|
|Purification||Antisera to mouse Glutathione peroxidase 4 (CT) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.|
|Immunogen||Synthetic peptide corresponding to amino acids near the carboxyl terminus of mouse glutathione peroxidase 4.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Phospholipid hydroperoxide glutathione peroxidase, mitochondrial, PHGPx, 184.108.40.206, Glutathione peroxidase 4, GPx-4, GSHPx-4, Gpx4|
|Target/Specificity||ABD11016 detects a specific epitope within the carboxy-terminal of mouse glutathione peroxidise 4 (GPx4) also known as phospholipid hydroperoxidase (PHGPx). GPx4 is a 20-22kDa selenoprotein that has an important role in preventing lipid peroxidation, and is thought to protect biomembranes against oxidative stress. GPx4 is expressed in high levels in testes, suggesting a role in male fertility. It has also been identified as an enzymatically inactive structural protein of the mitochondrial capsule of sperm. GPx4 has also been proposed as a modulator of various eicosanoids, which serve as inflammatory lipid signalling molecules.|
|Preservative & Stabilisers||0.01% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Mouse Glutathione Peroxidase 4 (Ct) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Nakagawa Y. (2004) Role of mitochondrial phospholipid hydroperoxide glutathione peroxidase (PHGPx) as an antiapoptotic factor.Biol. Pharm. Bull. 27: 956-960.
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