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Anti-Human EGF Receptor (C-Terminal) Antibody

Rabbit Anti-Human Polyclonal Antibody

  • IHC - Anti-Human EGF Receptor (C-Terminal) Antibody  ABD11019
    Staining of formalin fixed, paraffin embedded human ovarian carcinoma eith Rabbit anti Human EGR receptor
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P00533
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 134277 Da
Additional Information
Purification Antisera to human EGF R were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Immunogen Synthetic Peptide corresponding to the C-Terminal domain of Human EGF R, conjugated to Keyhole Limpet Hemocyanin (KLH).
Shelf Life 18 months from date of despatch.
Gene ID 1956
Other Names Epidermal growth factor receptor,, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, EGFR, ERBB, ERBB1, HER1
Target/Specificity ABD11019 recognises an epitope on the C-Terminal domain of Human Epidermal Growth Factor Receptor (EGFR, EGR-R), a 175 kDa transmembrane glycoprotein belonging to the ErbB receptor tyrosine kinase family. EGFR is the cell surface receptor for members of the EGF family, and functions in early embryonic development and in the renewal of stem cells in tissues such as the skin, liver and gut.EGFR is over expressed in a high proportion of breast cancer cells and in a range of other carcinomas, high level expression of EGFR is often associated with advanced disease and poor prognosis.Mutations to EGFR have been found in many human carcinomas including breast, brain, lung, and colon. Over-expression of more than one member of the ErbB family was found to have a negative synergistic effect on patient outcome.
Preservative & Stabilisers 0.1% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human EGF Receptor (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Moura, V. et al. (2012) Targeted and intracellular triggered delivery of therapeutics to cancer cells and the tumor microenvironment: impact on the treatment of breast cancer.
Breast Cancer Res Treat. 133: 61-73.

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Cat# ABD11019
(40 western blots)
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