|Calculated MW||93017 Da|
|Purification||Antisera to human CD156b were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared from whole serum by affinity chromatography.|
|Immunogen||Synthetic Peptide sequence corresponding to amino acids 807-823 of human CD156b|
|Shelf Life||18 months from date of despatch.|
|Other Names||Disintegrin and metalloproteinase domain-containing protein 17, ADAM 17, 18.104.22.168, TNF-alpha convertase, TNF-alpha-converting enzyme, CD156b, Adam17, Tace|
|Target/Specificity||Rabbit anti-Human CD156b antibody recognises Human CD156b, also known as ADAM17, a type I transmembrane glycoprotein which belongs to the ADAM (a disintegrin and metalloprotease domain) family.CD156b functions as a tumour necrosis factor-alpha converting enzyme (TACE). CD156b also causes a number of inflammatory modulators to undergo ectodomain shedding, including TNFR75, IL-1RII, TNFR55, L-selectin, and the amyloid precursor protein among others. CD156b plays a prominent role in the activation of the Notch signalling pathway.CD156b also plays a pivotal role in several acquired tumor cell capabilities by mediating the availability of soluble transforming growth factor-alpha, and establishing an autocrine signaling pathway through endogenous EGFR activation. CD156b is therefore a prospective therapeutic target in human cancer.|
|Preservative & Stabilisers||0.02% Sodium Azide (NaN3)|
|Storage||Store at +4℃. DO NOT FREEZE.|
|Precautions||Anti-Human CD156b Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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