|Calculated MW||20576 Da|
|Purification||Antiserum to human ATF3 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Synthetic peptide sequence corresponding to amino acid sequence 113-130 of human ATF3.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Cyclic AMP-dependent transcription factor ATF-3, cAMP-dependent transcription factor ATF-3, Activating transcription factor 3, ATF3|
|Target/Specificity||ABD11030 recognizes human Activating Transcription factor 3 (ATF3), a 20.6 kDa member of the activation transcription factor (ATF)/cCAMP responsive element-binding (CREB) family of transcription factors. Two isoforms of ATF3 have been identified. Isoform 1, the longer of the two, represses transcription from promoters with ATF binding elements by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2, which lacks the leucine zipper protein-dimerization motif, stimulates transcription, by sequestering inhibitory cofactors away from the promoters. It is possible that alternative splicing of the ATF3 gene may be physiologically important in the regulation of target genes .|
|Preservative & Stabilisers||0.01% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human ATF3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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