|Application ||WB, IHC-P, E|
|Calculated MW||81373 Da|
|Purification||Antiserum to human DAXX was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Synthetic peptide corresponding to amino acids 261-274 of human DAXX protein.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Death domain-associated protein 6, Daxx, hDaxx, ETS1-associated protein 1, EAP1, Fas death domain-associated protein, DAXX, BING2, DAP6|
|Target/Specificity||ABD11036 recognises human Death Domain-Associated Protein 6, a novel Fas binding protein that has been designated DAXX. DAXX binds specifically to the death domain of Fas and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway. DAXX is predominantly a nuclear protein, where it acts as a repressor of EtsI and Pax3 transactivation. When in association with ASK1 kinase DAXX translocates from the nucleus to the cytoplasm.|
|Preservative & Stabilisers||0.01% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human DAXX Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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