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Anti-Human Caspase-2 Antibody

Rabbit Anti-Human Polyclonal Antibody

  • IHC - Anti-Human Caspase-2 Antibody  ABD11037
    Staining of formalin fixed, parafin embedded human placenta with Rabbit anti Human caspase-2
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P42575
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 50685 Da
Additional Information
Other Species M
Purification Antiserum to human caspase-2 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Immunogen Synthetic peptide corresponding to 6 amino acid sequence from the amino-terminus of human Caspase-2.
Shelf Life 18 months from date of despatch.
Gene ID 835
Other Names Caspase-2, CASP-2,, Neural precursor cell expressed developmentally down-regulated protein 2, NEDD-2, Protease ICH-1, Caspase-2 subunit p18, Caspase-2 subunit p13, Caspase-2 subunit p12, CASP2, ICH1, NEDD2
Target/Specificity ABD11037 recognises human caspase-2, a 53 kDa member of the cysteine-aspartic acid protease (caspase) family. Caspase-2 is required for the permeabilisation of the mitochondria and the resulting amplification of caspase activity, in response to cytotoxic stress. Cytotoxic stress induced proteolytic cleavage of the caspase-2 proenzyme forms an active caspase which cleaves other caspases in a cascade. This leads to the release of cytochrome c and Smac from mitochondria and the translocation of Bax from the cytoplasm to the mitochondria, leading to apoptosis. In adults, caspase-2 is expressed in the placenta, lung, kidney, pancreas and at lower levels in the heart, brain, liver and skeletal muscle.
Preservative & Stabilisers 0.02% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human Caspase-2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD11037
(40 western blots)
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