|Application ||WB, IHC-P|
|Calculated MW||83971 Da|
|Purification||Antisera to human STIM2 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.|
|Immunogen||A 17 amino acid peptide located near the centre of human STIM2.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Stromal interaction molecule 2, STIM2, KIAA1482|
|Target/Specificity||ABD11039 recognises an internal region of stromal interaction molecule-2 (STIM2), a ubiquitously expressed type I membrane protein, of which at least three isoforms have been identified. In T-lymphocytes and other haematopoietic cells, the mechanism for increasing intracellular Ca2+, following antigen mediated T-cell activation, is through the store-operated Ca2+release-activated Ca2+ (CRAC) channels. STIM1 is reported to activate CRAC channels upon Ca2+depletion. Whereas, STIM2 acts to inhibit the STIM1-mediated store-operated Ca2+entry, and forms complexes with STIM1, suggesting that these molecules may play a co-ordinated role in controlling Ca2+entry.|
|Preservative & Stabilisers||0.02% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-STIM2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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