|Application ||WB, IHC-P, E|
|Calculated MW||48081 Da|
|Purification||Antiserum to human SMAD3 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Synthetic peptide corresponding to amino acids 417-425 of human SMAD3 protein.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Mothers against decapentaplegic homolog 3, MAD homolog 3, Mad3, Mothers against DPP homolog 3, hMAD-3, JV15-2, SMAD family member 3, SMAD 3, Smad3, hSMAD3, SMAD3, MADH3|
|Target/Specificity||ABD11048 recognises Mothers against decapentaplegic homolog 3 (SMAD3), a 50kDa transcriptional modulator activated by TGF-beta and activin type 1 receptor kinase, SMAD3 functions in cell proliferation, differentiation and development. Upon stimulation, SMAD3 oligomerizes with SMAD4 and translocates into the nucleus where it binds to DNA and transcription factors. SMAD3 activity induces differentiation of selected neuronal subtypes at the expense of other subtypes. Studies have indicated that defects in SMAD3 may be a cause of colorectal cancer.|
|Preservative & Stabilisers||0.01% Sodium Azide (NaN3)|
|Storage||Prior to reconstitution store at +4℃. Following reconstitution store at -20℃.|
|Precautions||Anti-SMAD3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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