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Anti-Human BRCA1 Antibody

Rabbit Anti-Human Polyclonal Antibody

  • WB - Anti-Human BRCA1 Antibody  ABD11049
    Detection of human BRCA1 in HeLa cell nuclear lysate by western blotting and immunoprecipitation with Rabbit anti Human BRCA1
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P38398
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 207721 Da
Additional Information
Purification Antiserum to human BRCA1 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Immunogen Synthetic peptide corresponding to an epitope within amino acid residues 1800-1863 of human BRCA1 (NP_009225.1).
Shelf Life 18 months from date of despatch.
Gene ID 672
Other Names Breast cancer type 1 susceptibility protein, 6.3.2.-, RING finger protein 53, BRCA1, RNF53
Target/Specificity ABD11049 specifically recognises human BRCA1 (breast cancer gene 1), a 220kDa nuclear phosphoprotein and tumour suppressor, involved in DNA damage repair, recombination and transcriptional regulation.The interaction between BRCA1 and BARD1 (BRCA1 associated RING domain 1) through an amino-terminal RING finger domain, is implicated in RNA processing following DNA damage, and also in the mediation of tumour suppression by BRCA1. Gene mutations in BRCA1 are known to greatly enhance susceptibility to inherited breast, breast-ovarian and prostate cancers, and BRCA1 is therefore commonly used as a diagnostic marker for breast cancer.
Preservative & Stabilisers 0.1% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human BRCA1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Venkitaraman, A.R. (2001) Functions of BRCA1 and BRCA2 in the biological response to DNA damage.
J. Cell Sci. 114: 3591-3598.

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Cat# ABD11049
(40 western blots)
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