|Application ||WB, IP|
|Calculated MW||207721 Da|
|Purification||Antiserum to human BRCA1 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Synthetic peptide corresponding to an epitope within amino acid residues 1800-1863 of human BRCA1 (NP_009225.1).|
|Shelf Life||18 months from date of despatch.|
|Other Names||Breast cancer type 1 susceptibility protein, 6.3.2.-, RING finger protein 53, BRCA1, RNF53|
|Target/Specificity||ABD11049 specifically recognises human BRCA1 (breast cancer gene 1), a 220kDa nuclear phosphoprotein and tumour suppressor, involved in DNA damage repair, recombination and transcriptional regulation.The interaction between BRCA1 and BARD1 (BRCA1 associated RING domain 1) through an amino-terminal RING finger domain, is implicated in RNA processing following DNA damage, and also in the mediation of tumour suppression by BRCA1. Gene mutations in BRCA1 are known to greatly enhance susceptibility to inherited breast, breast-ovarian and prostate cancers, and BRCA1 is therefore commonly used as a diagnostic marker for breast cancer.|
|Preservative & Stabilisers||0.1% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human BRCA1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Venkitaraman, A.R. (2001) Functions of BRCA1 and BRCA2 in the biological response to DNA damage. J. Cell Sci. 114: 3591-3598.
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