|Application ||WB, IP|
|Calculated MW||91362 Da|
|Purification||Antiserum to human Cdk11 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Synthetic peptide corresponding to an epitope within amino acid residues 730-780 of human Cdk11 (GeneID 985).|
|Shelf Life||18 months from date of despatch.|
|Other Names||Cyclin-dependent kinase 11A, 188.8.131.52, Cell division cycle 2-like protein kinase 2, Cell division protein kinase 11A, Galactosyltransferase-associated protein kinase p58/GTA, PITSLRE serine/threonine-protein kinase CDC2L2, CDK11A, CDC2L2, CDC2L3, PITSLREB|
|Target/Specificity||Rabbit anti-Human Cdk11 antibody recognizes human Cdk11 (cyclin-dependent kinase 11), otherwise known as CDC2L2, a ubiquitously expressed member of the p34cdc2 protein kinase family involved in cell cycle regulation and apoptosis, and linked with tumourigenesis.Three major isoforms of Cdk11 identified are the full length gene product Cdk11p110 and the shorter polypeptides Cdk11p58 and Cdk11p46. Cdk11p110 is a component of RNA polymerase II containing complexes involved in transcriptional regulation, and is implicated in pre-mRNA splicing through interaction with the splicing factor RNPS1 (RNA-binding protein with serine-rich domain 1). Cdk11p58 has been linked with mitosis, cell cycle arrest and apoptosis, and recently implicated as a negative regulator of the androgen receptor (AR) as part of a cyclin D3/ Cdk11p58 complex. Cdk11p46 arises from the cleavage of Cdk11p110 and Cdk11p58 by caspases following the induction of apoptosis, and is linked with apoptotic progression.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Cdk11 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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